Background: A few studies found that the complement system may be involved in the onset and progression of community-acquired pneumonia (CAP). However, the role of the complement system in CAP was ...

Complement may drive the pathology of hypertension through effects on innate and adaptive immune responses. Recently an injurious role for the anaphylatoxin receptors C3aR (complement component 3a ...

Preeclampsia (PE) is a prevalent life-threatening hypertensive disorder of pregnancy associated with increased complement activation. However, the causative factors and pathogenic role of increased ...

Mice were individually placed in the square arena, and allowed to explore the apparatus for 10 min while they were recorded to study their locomotor and exploratory activities (25). The arena was ...

The following is a summary of the “Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma” published in the November 2022 issue of Psychiatry by Luo et ...

Complement component C3a is an anaphylatoxin known to induce plasma exudation and smooth muscle contraction in tissues. The effects on inflammatory effector leukocytes, however, are poorly defined and ...

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in industrialized nations, affecting 30–50 million people worldwide. The earliest clinical hallmark of AMD is the ...