In addition to improving expression levels by the inclusion of NS4A or mRNA amplification by the SFV replicase, the immunogenicity of NS3 may possibly be improved by alternative modifications. One ...
A study conducted by researchers at Ohio State University and the New York University Grossman School of Medicine in the USA, has revealed that optimization of codon for bacterial expression causes ...
The main focus of this study is, to understand provision of reducing impact of frame shift mutations in genetic code table, which may occur when protein translation starts not at the first nucleotide ...
Tuning mRNA sequences based on tRNA gene copy number data Analyzing and comparing translation speed properties between native and host organisms Supporting multiple organisms with customizable options ...
Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It is used extensively for expressing recombinant protein drugs, gene therapy ...
Abstract: Codon language modeling is an emerging area of research interest. Prior efforts in codon optimization have mostly focused on the effect codon preferences have on protein translation speed ...
Motivation: Codon optimization of Open Reading Frame (ORF) sequences is essential for enhancing mRNA stability and expression in applications like mRNA vaccines, where codon choice can significantly ...
Two studies provide insights into the distinct strategies used by prokaryotes and eukaryotes to pause translation in order to facilitate cotranslational targeting of membrane proteins to the ...
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