If you look at a nerve cell, a muscle cell, or a skin cell under the microscope, they appear strikingly different. However, every cell in our body has the same DNA and has descended from a common ...

During embryonic development, cells start out as pluripotent, or have the potential to become many different cell types through differentiation. Naive-state is the name for the earliest stage of ...

Ligand-driven enhancer activation selectively boosts target gene expression while indirectly repressing neighboring non-target genes, revealing dynamic and competitive regulation during early ...

Genome-wide association studies (GWASs) have linked genetic variants to neuropsychiatric disorders, but their regulatory roles in non-coding regions remain largely unclear. Using the LUHMES neuronal ...

Scientists usually study the molecular machinery that controls gene expression from the perspective of a linear, two-dimensional genome—even though DNA and its bound proteins function in three ...

(L to R) Corresponding author Brian Abraham, PhD, and co-first authors Kelsey Maher, PhD, and co-first author Jie Lu, PhD, all of the St. Jude Department of Computational Biology. Cells express ...