Mendelian randomization is an approach to causal inference that uses genetic variants as instrumental variables to estimate causal effects of a risk factor on disease or health outcomes. Methods ...

A groundbreaking new book – the first of its kind in Chinese – is now available to empower researchers with the powerful tool of Mendelian randomization. Translated from the esteemed text "Mendelian ...

Researchers at Columbia University Mailman School of Public Health have developed a novel computational pipeline designed to identify protein biomarkers associated with complex diseases, including ...

Using MR-SPI and AlphaFold3, scientists unravel the molecular underpinnings of Alzheimer’s disease, identifying key protein changes that could reshape future treatments. Study: Deciphering proteins in ...

Many genes and proteins have been linked to Alzheimer’s, but which ones directly contribute to disease? This question has been hard to answer. In the December 11 Cell Genomics, scientists led by ...