PHILADELPHIA -- Researchers long thought that only one strand of a double-stranded microRNA can silence genes. Though recent evidence has challenged that dogma, it's unclear what the other strand does ...

Scientists have shown that small RNA molecules occurring naturally in cells, i.e. microRNAs, are also abundant in cell nuclei. Previously, microRNAs were mainly thought to be found in cytoplasm. The ...

Researchers have found that levels of methylated microRNA were significantly higher in tissue and serum from cancer patients compared with that from normal controls. Specifically, methylation levels ...

Comparative effectiveness of treatment strategies for urothelial cancer of the bladder (UCB) with clinical lymph node involvement (cN+). Anti-tumor activity, safety and pharmacokinetics (PK) of AGS15E ...

The authors provide further insight into microRNA biology, and the simplicity of anti-miR oligonucleotide drug delivery. RNA-based therapeutics hold significant potential as promising treatment ...

This year’s Nobel Prize in Medicine was awarded to Victor Ambros and Gary Ruvkun, as announced by the Nobel Assembly at the Karolinska Institute in Stockholm on October 7. Gary Ruvkun, professor of ...

Please provide your email address to receive an email when new articles are posted on . The Nobel Assembly at Karolinska Institutet in Sweden announced the honor today. Victor R. Ambros, PhD, and Gary ...

microRNAs (miRNA), non-coding RNA molecules, are widely known for regulating mRNA stability and translation. miR-10b has been increasingly implicated in the pathogenesis of gliomas, cancers of the ...

In the October15th issue of G&D, Dr. Fen-Biao Gao and colleagues at UCSF report that microRNA-9a (mir-9a) regulates neural development in the fruit fly, Drosophila. Using loss-of-function analysis, Dr ...