Oocyte growth and maturation depend on a finely tuned exchange of metabolic substrates and signals between the female germ cell and its surrounding somatic or supporting cells. Within the ovarian ...

Dr. Shannon Sinsheimer, ND   Subheadline A clinical review of mitochondrial dysfunction, oxidative stress, and ...

Declining female fertility is a health issue that has received broad global attention. Oocyte quality is the key limiting factor of female fertility, and factors affecting oocyte quality involve the ...

The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer's. A study now finds that the build-up of these ...

Researchers have found that a carefully orchestrated act of X-chromosome 'yoyo' predicts the successful and efficient development of mammalian egg cells. The findings could pave the way for generating ...

The new method offers researchers a powerful new platform to investigate the molecular mechanisms that control oogenesis, the process by which egg cells develop, and lays important groundwork for ...

Researchers led by Kyushu University have succeeded in using mouse stem cells to reconstruct structures in the ovarian environment critical for the generation of mature egg cells. Moreover, they were ...

Mature egg cells, or oocytes, are essential for fertilization in assisted reproductive technologies. However, some 'denuded' oocytes, or those lacking the protective granulosa cell layer, fail to ...

Oocytes are immature egg cells that develop in almost all female mammals before birth. The propagation of future generations depends on this finite reserve of cells surviving for many years without ...