Phylo-Plex, a new computational method, has been developed by Wellcome Sanger Institute scientists and their collaborators to allow cost-effective and scalable DNA sequencing of pathogens in ...
Genetic variants that cause rare disorders may remain elusive even after expansive testing, such as exome sequencing. The diagnostic yield of genome sequencing, particularly after a negative ...
Single-cell RNA-seq AI analysis has become the default way to make sense of the millions of expression measurements a single experiment can now generate. Turning raw sequencing counts into ...
Within each of our cells, long strands of DNA are folded into chromosomes and capped with protective structures called telomeres. But telomeres shorten as we age, eventually getting so whittled down ...
DNA-based methods dominate molecular cancer diagnostics but struggle to detect gene fusions and assess splice site consequences. RNA sequencing enables sensitive fusion detection and direct assessment ...
Morgan Hiebert (left) studies drug-resistant tuberculosis within the National Reference Centre for Mycobacteriology (Winnipeg, Manitoba) led by Hafid Soualhine, situated in the National Microbiology ...
Evaluation of scCNV inference methods using a clinical small cell lung cancer (SCLC) dataset. (A) Sensitivity and specificity of the four scCNV inference methods applied to primary and relapse SCLC ...
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