A wave of spatial transcriptomics studies has produced gene-expression atlases that span entire organs and whole organisms, ...

Andreas Pfenning discusses the techniques being developed and used to study neuronal heterogeneity and the therapeutic potential of his work.

Spatial transcriptomics and gene expression analysis represent a transformative approach in biomedical research, integrating the spatial context of tissues with high-resolution profiling of gene ...

Biological systems are inherently three-dimensional—tissues form intricate layers, networks, and architectures where cells interact in ways that extend far beyond a flat plane. To capture the true ...

Spatial transcriptomics is a technique that provides information about gene expression patterns within intact tissues. This technology employs various methodologies, including in situ sequencing (ISS) ...

Tumors contain many different types of cells organized in complex spatial patterns that can influence how the disease progresses. Because of this, it is hard to predict how a tumor will develop and ...

This illustration summarizes how integrated spatial transcriptomics, single-cell transcriptomics, single-cell epigenomics, and spatial epigenomics enable multi-dimensional profiling of the tumor ...

Knowing the location of a gene within intact tissue or a single cell allows scientists to unlock unknown cellular functions. This information is often lost in most genetic sequencing techniques, but ...

Mount Sinai researchers have published the first organ-wide human skin spatial atlas from across the body. It provides an ...